Duprat P, Delsaut L, Gradiski D
Eur J Toxicol Environ Hyg. 1976 May-Jun;9(3):171-7.
A study was carried out in the rabbit in order to compare the cutaneous and ocular mucosa irritant powers of the principal aliphatic chloride solvents and of pure hexachlorobutadiene. Using Draize's method, that of the official technique for the assessment of cosmetic products and the interpretation of Kay and Calandra, a study was made of the effects of a single application or instillation of the common aliphatic chloride solvents. Macroscopic observations were followed by histological examination of the lesions and their course. With the exception of trichloro trifluoro-1,2,3-ethane, these substances are primary irritants but their effects on rabbit skin and ocular mucosa differ.
为了比较主要脂肪族氯化溶剂和纯六氯丁二烯对皮肤和眼黏膜的刺激能力，在兔子身上进行了一项研究。采用德雷兹方法（这是评估化妆品的官方技术以及凯和卡兰德拉的解释方法），对常见脂肪族氯化溶剂单次涂抹或滴入的效果进行了研究。在宏观观察之后，对病变及其发展过程进行了组织学检查。除了三氯三氟 - 1,2,3 - 乙烷外，这些物质都是原发性刺激物，但它们对兔皮和眼黏膜的影响有所不同。
