Zhu X, Su B, Wang X, Smith M A, Perry G
Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
Cell Mol Life Sci. 2007 Sep;64(17):2202-10. doi: 10.1007/s00018-007-7218-4.
Oxidative stress is one of the earliest events of Alzheimer disease (AD), with implications as an important mediator in the onset, progression and pathogenesis of the disease. The generation of reactive oxygen species (ROS) and its consequent cellular damage/response contributes to much of the hallmark AD pathology seen in susceptible neurons. The sources of ROS-mediated damage appear to be multi-faceted in AD, with interactions between abnormal mitochondria, redox transition metals, and other factors. In this review, we provide an overview of these potential causes of oxidative stress in AD.
氧化应激是阿尔茨海默病（AD）最早出现的事件之一，是该疾病发生、发展及发病机制中的重要介导因素。活性氧（ROS）的产生及其导致的细胞损伤/反应在易感神经元中导致了许多AD标志性病理特征。在AD中，ROS介导的损伤来源似乎是多方面的，涉及异常线粒体、氧化还原过渡金属及其他因素之间的相互作用。在本综述中，我们概述了AD中氧化应激的这些潜在原因。
