Eickhoff J H, Göte H, Baeck J
Department of Surgery K, Frederiksberg Hospital, Copenhagen, Denmark.
Br J Urol. 1991 Dec;68(6):608-11. doi: 10.1111/j.1464-410x.1991.tb15424.x.
Several reports have suggested that peri-operative blood transfusion promotes tumour recurrence and death after surgery for cancer. We have studied the effect of transfusion in 156 patients operated on for prostatic cancer. A retrospective review was made of the clinical, histopathological and transfusion data in their hospital records. Sixty patients received blood transfusions and 96 did not. The 5-year prostatic cancer specific survival rate was 0.56 in the transfused patients and 0.69 in the non-transfused group. The transfused patients had a higher prevalence of risk factors than did the non-transfused. When the differences in risk factors were accounted for by Cox regression analysis, peri-operative blood transfusion reduced the prostatic cancer death intensity by 36%. The study does not support the hypothesis that blood transfusion promotes recurrence following surgery for prostatic cancer.
几份报告表明，围手术期输血会促进癌症手术后肿瘤复发和死亡。我们研究了156例接受前列腺癌手术患者的输血影响。对他们医院记录中的临床、组织病理学和输血数据进行了回顾性分析。60例患者接受了输血，96例未输血。输血患者的5年前列腺癌特异性生存率为0.56，未输血组为0.69。输血患者的危险因素患病率高于未输血患者。通过Cox回归分析考虑危险因素的差异后，围手术期输血使前列腺癌死亡强度降低了36%。该研究不支持输血会促进前列腺癌手术后复发这一假设。
