Xiao Ding-hua, Shen Shou-rong, Xu Can-xia, Tang Wu-liang, Wang Xiao-yan, Wang Fen
Department of Gastroenterology, Third Xiangya Hospital, Central South University,Changsha 410013, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2007 Jun;32(3):443-6.
To investigate the efficacy and security of different uses of propofol on the sedation during the upper gastrointestinal endoscopic procedures.
Four hundred patients who underwent gastroscopy received midazolam and propofol as sedation. Patients were divided to 4 groups with different intervals between midazolam and propofol: Group A and D with the interval of 30 seconds to 1 minute, Group B and C with 3 to 5 minute interval. All patients were premedicated with midazolam and propofol at 16 approximately 25 mg/10s (Group A and B) and 6 approximately 7 mg/10s (Group C and D).
The doses of propofol of Group A,B,C, and D were (111.90+/-22.43),(102.20+/-15.99),(73.05+/-13.08) and (80.90+/-17.36)mg respectively, with significant difference(P<0.01). The time of return to consciousness decreased markedly in Group C and D [(9+/-1), (10+/-2)min ], and that of Group A and B was [(14+/-5), (13+/-3)min ]. There was significant difference between Group C, D and Group A, B(P<0.01).
The dose of propofol and the time of return to consciousness depend on the rate of administration and the interval between midazolam and propofol. Appropriate rate and interval can produce safer and more effective sedation for the upper gastrointestinal endoscopic procedure.
探讨丙泊酚不同使用方式在上消化道内镜检查术中镇静的有效性及安全性。
400例行胃镜检查的患者接受咪达唑仑和丙泊酚镇静。患者按咪达唑仑与丙泊酚给药间隔不同分为4组：A组和D组间隔为30秒至1分钟，B组和C组间隔为3至5分钟。所有患者均予咪达唑仑及丙泊酚预处理，给药速度分别约为16至25mg/10s（A组和B组）及6至7mg/10s（C组和D组）。
A、B、C、D组丙泊酚用量分别为(111.90±22.43)、(102.20±15.99)、(73.05±13.08)及(80.90±17.36)mg，差异有统计学意义（P<0.01）。C组和D组清醒时间明显缩短[分别为(9±1)、(10±2)分钟]，A组和B组为[(14±5)、(13±3)分钟]。C、D组与A、B组比较差异有统计学意义（P<0.01）。
丙泊酚用量及清醒时间取决于给药速度及咪达唑仑与丙泊酚的给药间隔。合适的速度和间隔可为上消化道内镜检查术提供更安全有效的镇静。
