单次口服仑氨西林后人体口腔组织中的氨苄西林浓度。

Ampicillin concentrations in human oral tissues following a single oral administration of lenampicillin.

Akimoto Y, Mochizuki Y, Uda A, Omata H, Shibutani J, Kaneko K, Yamane J, Fujii A, Yamamoto H

Second Department of Oral Surgery, Nihon University School of Dentistry, Chiba, Japan.

Gen Pharmacol. 1991;22(5):797-800. doi: 10.1016/0306-3623(91)90208-n.

Abstract

Ampicillin concentrations in serum (n = 20), gingiva (n = 12), jawbone (n = 13), dental follicle (n = 12), radicular granuloma (n = 2) and radicular cyst (n = 2) were measured in specimens obtained during 0.5-2.5 hr after a single oral administration of lenampicillin (equivalent to 500 mg of ampicillin). 2. Measurable ampicillin concentrations were found in all serum and tissues. 3. Ampicillin concentrations in serum and tissues except for some gingiva and jawbone exceeded MIC for 90% of clinically isolated strains of alpha-hemolytic Streptococci. 4. Ampicillin concentrations in gingiva and jawbone were below the MIC for 90% in 2 out of 12 and 4 out of 13 specimens, respectively.

摘要

在单次口服伦氨西林（相当于500mg氨苄西林）后0.5 - 2.5小时内获取的标本中，测量了血清（n = 20）、牙龈（n = 12）、颌骨（n = 13）、牙囊（n = 12）、根尖肉芽肿（n = 2）和根尖囊肿（n = 2）中的氨苄西林浓度。2. 在所有血清和组织中均发现了可测量的氨苄西林浓度。3. 除部分牙龈和颌骨外，血清和组织中的氨苄西林浓度超过了90%临床分离的α - 溶血性链球菌菌株的最低抑菌浓度（MIC）。4. 牙龈和颌骨中的氨苄西林浓度在12个标本中有2个、13个标本中有4个分别低于90%的最低抑菌浓度。