Lammerding Jan, Dahl Kris Noel, Discher Dennis E, Kamm Roger D
Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital,/Harvard Medical School, Boston, Massachusetts 02115, USA.
Methods Cell Biol. 2007;83:269-94. doi: 10.1016/S0091-679X(07)83011-1.
The role of the nucleus in protecting and sequestering the genome is intrinsically mechanical, and disease-causing structural mutants in lamins and other components underscore this function. Various methods to measure nuclear mechanics, isolated or in situ, are outlined here in some detail.
细胞核在保护和隔离基因组方面的作用本质上是机械性的，核纤层蛋白和其他成分中导致疾病的结构突变体突出了这一功能。本文将详细概述各种测量细胞核力学的方法，包括离体或原位测量。
