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具有非典型临床表现的结外型T/NK细胞淋巴瘤。

Extranodal type T/NK-cell lymphoma with an atypical clinical presentation.

作者信息

Aydin G Burça, Akyuz Canan, Talim Beril, Evans Sibel Ersoy, Sahin Sedef, Sari Neriman, Tabanlioglu Duru, Ozen Seza, Cağlar Melda, Büyükpamukçu Münevver

机构信息

Department of Pediatric Oncology, Hacettepe University, Institute of Oncology, Ankara, Turkey.

出版信息

Pediatr Hematol Oncol. 2007 Jun;24(4):291-9. doi: 10.1080/08880010701441112.

Abstract

Peripheral-type natural killer (NK)- or T-cell lymphomas are rare disorders characterized with clonal proliferation of mature lymphocytes. They have been linked to chronic and active Epstein-Barr virus infection (CAEBV), which itself is not defined as a malignant hematological disorder. The authors present a patient with T/NK-cell lymphoma involving skin, kidneys, spleen, pancreas, and meninges. She was remarkable for having the mosaic feature of more than one type of extranodal T/NK-cell lymphoma. She also had mixed findings of CAEBV that might have been attributed both to hypersensitivity to mosquito bites and to hemophagocytic lymphohistiocytosis.

摘要

外周型自然杀伤(NK)细胞或T细胞淋巴瘤是罕见的疾病,其特征为成熟淋巴细胞的克隆性增殖。它们与慢性活动性EB病毒感染(CAEBV)有关,而CAEBV本身并不被定义为恶性血液系统疾病。作者报告了一例T/NK细胞淋巴瘤累及皮肤、肾脏、脾脏、胰腺和脑膜的患者。她的显著特点是具有不止一种类型的结外T/NK细胞淋巴瘤的镶嵌特征。她还具有CAEBV的混合表现,这可能既归因于对蚊虫叮咬的超敏反应,也归因于噬血细胞性淋巴组织细胞增生症。

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