迈向褪黑素在前列腺癌预防和治疗中的合理及循证应用。

Towards rational and evidence-based use of melatonin in prostate cancer prevention and treatment.

作者信息

Shiu Stephen Y W

机构信息

Department of Physiology, The University of Hong Kong, Hong Kong, China.

出版信息

J Pineal Res. 2007 Aug;43(1):1-9. doi: 10.1111/j.1600-079X.2007.00451.x.

DOI:10.1111/j.1600-079X.2007.00451.x

PMID:17614829

Abstract

Prostate cancer is a public health problem of the elderly men. It has been estimated that one in six men will develop prostate cancer in his lifetime in the USA. There is thus a huge clinical demand for effective therapies for the prevention and treatment of the disease. Here, the scientific evidence supporting the effectiveness of melatonin in inhibiting the development and progression of prostate cancer is reviewed. The rational use of melatonin in prostate cancer prevention, stabilization of clinically localized favourable-risk prostate cancer and palliative treatment of advanced or metastatic tumour is discussed within the context of the molecular pathogenesis of the disease.

摘要

前列腺癌是老年男性的一个公共卫生问题。据估计，在美国每六个男性中就有一人在其一生中会患上前列腺癌。因此，对于预防和治疗该疾病的有效疗法存在巨大的临床需求。在此，综述了支持褪黑素抑制前列腺癌发生和进展有效性的科学证据。在该疾病分子发病机制的背景下，讨论了褪黑素在前列腺癌预防、临床局限性低危前列腺癌稳定以及晚期或转移性肿瘤姑息治疗中的合理应用。