Sazawal Sunil, Dhingra Usha, Deb Saikat, Bhan Maharaj K, Menon Venugopal P, Black Robert E
Department of International Health, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Room W5517, Baltimore, MD 21205, USA.
J Health Popul Nutr. 2007 Mar;25(1):62-6.
In a community-based double-blind randomized trial in children aged 6-35 months, both intervention and control groups received a multi-vitamin syrup containing vitamin A, while the intervention group had zinc gluconate (equivalent to 10 mg of elemental zinc) additional in the syrup. There was a significant decrease in diarrhoea and pneumonia in the intervention group. This study was undertaken to investigate if addition of zinc to vitamin A had improved plasma retinol levels, which, in turn, was responsible for the effects observed in the intervention group. In a randomly-selected subsample of 200 children--100 each from the intervention and the control group, plasma retinol levels after 120 days of supplementation were measured. There was no difference in the mean plasma retinol levels [the difference in the mean 0.46 microg/dL (95% confidence interval -1.42-2.36)] between the two groups following supplementation. No difference in plasma retinol levels was observed in the subgroups based on base-line nutritional status and plasma zinc levels. Addition of zinc to low-dose vitamin A in this study did not improve the vitamin A status of children and cannot explain morbidity effects of the intervention.
在一项针对6至35个月大儿童的社区双盲随机试验中，干预组和对照组均接受了含有维生素A的多种维生素糖浆，而干预组的糖浆中额外添加了葡萄糖酸锌（相当于10毫克元素锌）。干预组的腹泻和肺炎发生率显著降低。本研究旨在调查在维生素A中添加锌是否能提高血浆视黄醇水平，而这反过来又导致了干预组中观察到的效果。在随机抽取的200名儿童子样本中——干预组和对照组各100名，测量了补充120天后的血浆视黄醇水平。补充后两组之间的平均血浆视黄醇水平没有差异[平均差异为0.46微克/分升（95%置信区间为-1.42至2.36）]。在基于基线营养状况和血浆锌水平的亚组中，未观察到血浆视黄醇水平有差异。在本研究中，在低剂量维生素A中添加锌并不能改善儿童的维生素A状况，也无法解释干预措施对发病率的影响。
