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Indomethacin-sensitive monocyte killing defect in a child with disseminated atypical mycobacterial disease.

作者信息

Ridgway D, Wolff L J, Wall M, Borzy M S, Kirkpatrick C H

机构信息

Department of Pediatrics, Doernbecher Memorial Hospital for Children, Portland, Oregon 97201-3042.

出版信息

J Clin Immunol. 1991 Nov;11(6):357-62. doi: 10.1007/BF00918801.

DOI:10.1007/BF00918801
PMID:1761641
Abstract

A child with disseminated disease due to Mycobacterium avium had progressive disease in spite of 4.5 years of therapy with multiple antimicrobial agents selected on the basis of in vitro sensitivity testing of her organism. A defect in monocyte bactericidal activity was detected which was corrected in vitro by exposure of the patient's monocytes to indomethacin and normal serum. Indomethacin therapy resulted in normalization of monocyte bactericidal activity and striking, albeit temporary, clinical improvement.

摘要

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本文引用的文献

1
Nontuberculous mycobacterial endobronchitis in children.儿童非结核分枝杆菌性支气管内膜炎
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9
Mycobacterium fortuitum infection: evidence of bactericidal defect due to hyperactive antigen-specific suppressor cells. Correction in vitro and in vivo by cholinergic agonist and indomethacin.偶然分枝杆菌感染：因高活性抗原特异性抑制细胞导致杀菌缺陷的证据。胆碱能激动剂和吲哚美辛在体外和体内的纠正作用。
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Disease in children due to mycobacteria other than Mycobacterium tuberculosis.儿童由非结核分枝杆菌引起的疾病。
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