适用于监测多药抗惊厥治疗的卡马西平快速灵敏液相色谱测定法。
Rapid and sensitive liquid chromatographic determination of carbamazepine suitable for use in monitoring multiple-drug anticonvulsant therapy.
作者信息
Westenberg H G, de Zeeuw R A
出版信息
J Chromatogr. 1976 Mar 17;118(2):217-24. doi: 10.1016/s0021-9673(00)81210-8.
PMID:176168
Abstract
A rapid, sensitive and selective method for the determination of carbamazepine and its major metabolite in plasma has been developed. Other commonly used anticonvulsants can be determined in the same procedure without interference. After extraction with dichloromethane, the components are separated by high-pressure liquid chromatography without further clean-up or concentration on a column packed with small-particle silica gel. The mean recovery from plasma is 98.6% with a relative standard deviation of 1.6%. The detection limit for carbamazepine is approximately 2 ng/ml, requiring 1 ml of plasma.
摘要
已开发出一种快速、灵敏且选择性强的方法，用于测定血浆中卡马西平及其主要代谢物。其他常用的抗惊厥药可在同一程序中测定而不受干扰。用二氯甲烷萃取后，各组分通过高压液相色谱法分离，无需在填充有小颗粒硅胶的柱上进一步净化或浓缩。血浆的平均回收率为98.6%，相对标准偏差为1.6%。卡马西平的检测限约为2 ng/ml，需要1 ml血浆。
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