肿瘤坏死因子-α在斯内登-威尔金森角层下脓疱性皮肤病中的作用。一种体内中性粒细胞启动的模型。
Role of tumor necrosis factor-alpha in Sneddon-Wilkinson subcorneal pustular dermatosis. A model of neutrophil priming in vivo.
作者信息
Grob J J, Mege J L, Capo C, Jancovicci E, Fournerie J R, Bongrand P, Bonerandi J J
机构信息
Service de Dermatologie, Hôpital Sainte Marguerite, Marseille, France.
出版信息
J Am Acad Dermatol. 1991 Nov;25(5 Pt 2):944-7. doi: 10.1016/0190-9622(91)70290-i.
A patient with IgG-kappa-associated subcorneal pustular dermatosis (Sneddon-Wilkinson disease) refractory to dapsone, etretinate, and plasma exchange was successfully treated with corticosteroids. A study of neutrophils from both blood and pustules was carried out before and during treatment. Levels of tumor necrosis factor-alpha were measured in serum, pustules, content, and supernatant of monocytes. The results suggest that a hyperactivation of neutrophils in the skin is due at least partly to excessive production of tumor necrosis factor-alpha.
一名对氨苯砜、阿维A酯和血浆置换治疗无效的IgG-κ相关角层下脓疱性皮病（斯奈登-威尔金森病）患者，使用皮质类固醇治疗成功。在治疗前和治疗期间，对血液和脓疱中的中性粒细胞进行了研究。测量了血清、脓疱、单核细胞内容物和上清液中肿瘤坏死因子-α的水平。结果表明，皮肤中中性粒细胞的过度活化至少部分归因于肿瘤坏死因子-α的过量产生。
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