孕早期妊娠囊内叶酸的转运及孕妇吸烟的影响

Transfer of folic acid inside the first-trimester gestational sac and the effect of maternal smoking.

作者信息

Jauniaux Eric, Johns Jemma, Gulbis Beatrice, Spasic-Boskovic Olivera, Burton Graham J

机构信息

Academic Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, London, United Kingdom.

出版信息

Am J Obstet Gynecol. 2007 Jul;197(1):58.e1-6. doi: 10.1016/j.ajog.2007.02.009.

DOI:10.1016/j.ajog.2007.02.009

PMID:17618758

Abstract

OBJECTIVE

The objective of the study was to investigate the transfer pathways of folic acid inside the first-trimester gestational sac and to evaluate the impact of maternal smoking.

STUDY DESIGN

Folate and cotinine levels were evaluated in maternal serum (n = 125) and coelomic fluid (n = 42), and immunostaining was used to identify folate receptors in placental villi, decidual tissue, and secondary yolk sacs from normal pregnancies at 6-12 weeks' gestation.

RESULTS

Folate receptors-alpha were found on the apical surface of syncytiotrophoblast, uterine glandular epithelial cells, and mesothelial layer of the yolk sac. Significantly higher (P < .05) median folate levels were found in maternal serum than in coelomic fluid. The median folate maternal serum and coelomic levels were significantly (P < .0001 and P < .005) lower in smokers, compared with nonsmokers.

CONCLUSION

Uterine glands and the secondary yolk sac play key roles in supplying folic acid to the developing fetus before the placental circulations are established, and maternal smoking does not seem to impair directly its transfer mechanism in early pregnancy.

摘要