Department of Environmental Medicine, Slovak Medical University, Limbová 12, 83303, Bratislava, Slovakia.
Environ Sci Pollut Res Int. 2013 Dec;20(12):8557-66. doi: 10.1007/s11356-013-1786-7. Epub 2013 May 16.
The aim of this study was to relate placental transfer, quantified by the cord to maternal serum concentration ratio (C/M), of five organochlorine pesticides (OCP) hexachlorobenzene (HCB), β-hexachlorocyclohexane (β-HCH), γ-hexachlorocyclohexane (γ-HCH) , p,p'-DDT, p,p'-DDE and 15 polychlorinated biphenyl (PCB) congeners (28, 52, 101, 105, 114, 118, 123(+149), 138(+163), 153, 156(+171), 157, 167, 170, 180, and 189) to anthropometric, socioeconomic, and maternal health characteristics. We included into the study 1,134 births during the period 2002-2004 from two districts in eastern Slovakia with high organochlorine concentrations relative to other areas of the world. Only concentrations >LOD were taken into account. Variables as age, weight and height of mothers, parity, ethnicity, alcohol consumption, illness during pregnancy, smoking during pregnancy, hypertension, respiratory diseases, rheumatoid arthritis and diabetes mellitus, and birth weight were related to C/M. Results of regression analyses showed that C/M was predicted by several factors studied. Positive associations were observed for gestational alcohol consumption, fewer illnesses during pregnancy, maternal age, and maternal weight. Caucasians had a greater C/M compared to Romani for wet weight data of congeners 170 and 180 and in contrast C/M for HCB was greater in Romani. Our results show that drinking mothers compared to abstaining expose their fetuses not only to alcohol but to an increased level of several PCB congeners. A straightforward explanation of associations between C/M shifts and factors studied is very difficult, however, with regard to the high lipophilicity of OCPs and PCBs, changes in their kinetics probably reflect lipid kinetics.
本研究旨在探讨胎盘转运，以脐带与母体血清浓度比（C/M）来定量，与五种有机氯农药（OCP）六氯苯（HCB）、β-六氯环己烷（β-HCH）、γ-六氯环己烷（γ-HCH）、p,p'-滴滴涕、p,p'-滴滴伊和 15 种多氯联苯（PCB）同系物（28、52、101、105、114、118、123（+149）、138（+163）、153、156（+171）、157、167、170、180 和 189）的人体测量、社会经济和产妇健康特征有关。我们纳入了 2002-2004 年来自斯洛伐克东部两个区的 1134 例分娩，这些地区的有机氯浓度相对世界其他地区较高。只有高于检测限（LOD）的浓度才被考虑在内。母亲的年龄、体重和身高、产次、种族、饮酒、怀孕期间的疾病、怀孕期间吸烟、高血压、呼吸道疾病、类风湿关节炎和糖尿病以及出生体重等变量与 C/M 有关。回归分析结果表明，C/M 受到所研究的多个因素的预测。研究发现，妊娠期间饮酒、怀孕期间疾病减少、母亲年龄和母亲体重与 C/M 呈正相关。与罗姆人相比，白种人对同系物 170 和 180 的湿重数据和 HCB 的 C/M 更高。我们的结果表明，与不饮酒的母亲相比，饮酒的母亲不仅会使胎儿暴露于酒精中，还会使胎儿暴露于几种 PCB 同系物的水平升高。然而，要对 C/M 变化与所研究的因素之间的关联做出简单的解释非常困难，鉴于 OCP 和 PCB 的高亲脂性，它们的动力学变化可能反映了脂质动力学。
