[念珠菌血症血清学抗原检测试验的临床评估]

[Clinical evaluation of serological antigen detection tests for candidemia].

作者信息

Maesaki S, Kohno S, Yamada H, Mitsutake K, Sugiyama H, Hori H, Kaku M, Koga H, Hara K, Seto M

机构信息

2nd Department of Internal Medicine, School of Medicine, Nagasaki University.

出版信息

Kansenshogaku Zasshi. 1991 Sep;65(9):1091-6. doi: 10.11150/kansenshogakuzasshi1970.65.1091.

DOI:10.11150/kansenshogakuzasshi1970.65.1091

PMID:1761890

Abstract

The new serological tests for candidemia were evaluated. In nine cases of candidemia, fungal index (Endotoxin D-Endospecy) was 146.8 +/- 116.8 pg/ml and D-arabinitol/creatinine 1.10 +/- 1.04 mumol/mg. Fungal index was significantly (p less than 0.01) higher in candidemia than suspected infections. All candidemia were positive for Cand-Tec latex agglutination, but twelve of the sixteen cases of suspected infections were also positive. Mannan latex agglutination was very specific for candidemia. Four cases of candidemia was positive for Mannan latex agglutination and only one case was positive in suspected infections. Fungal index and D-arabinitol/creatinine was decreased after treatment of antifungal agents. In poor clinical efficacy case, these titer remained high even after treatment. These data suggested the usefulness of these serological tests for candidemia.

摘要

对新型念珠菌血症血清学检测方法进行了评估。在9例念珠菌血症病例中，真菌指数（内毒素D - 内毒素检测法）为146.8±116.8 pg/ml，D - 阿拉伯糖醇/肌酐为1.10±1.04 μmol/mg。念珠菌血症患者的真菌指数显著高于疑似感染患者（p<0.01）。所有念珠菌血症病例的Cand - Tec乳胶凝集试验均为阳性，但16例疑似感染病例中有12例也呈阳性。甘露聚糖乳胶凝集试验对念珠菌血症具有高度特异性。4例念珠菌血症病例的甘露聚糖乳胶凝集试验呈阳性，而疑似感染病例中只有1例呈阳性。抗真菌药物治疗后，真菌指数和D - 阿拉伯糖醇/肌酐降低。临床疗效不佳的病例，即使治疗后这些指标仍维持在较高水平。这些数据表明这些血清学检测方法对念珠菌血症诊断具有实用价值。