Ozawa N
Department of Orthopaedic Surgery, Yokohama City University School of Medicine, Kanagawa, Japan.
Nihon Seikeigeka Gakkai Zasshi. 1991 Nov;65(11):1091-8.
Sintered porous hydroxyapatite blocks (3 x 3 x 4 and 5 x 5 x 5) were implanted into the calcaneal tendons of 64 Wistar rats to observe tissue reaction and interconnection. Histological observations and measurements of mechanical strength of the interconnection were performed at 1 to 24 weeks after the implantation surgery. The implants were found to be surrounded by connective tissue consisting of small, round cells which infiltrated into micropores of the hydroxyapatite blocks. Neither calcifications nor inflammatory reactions were observed. The mechanical strength at the interconnection increased significantly from 1 week to 8 weeks after the implantation, which then reached the peak of 1.3 +/- 0.3 kg/cm2 at 8 weeks.
将烧结多孔羟基磷灰石块（3×3×4和5×5×5）植入64只Wistar大鼠的跟腱中，以观察组织反应和连接情况。在植入手术后1至24周进行组织学观察和连接部位机械强度的测量。发现植入物被由小圆形细胞组成的结缔组织包围，这些细胞浸润到羟基磷灰石块的微孔中。未观察到钙化或炎症反应。植入后1周时连接部位的机械强度显著增加，至8周时达到峰值1.3±0.3kg/cm²。
