Negami S
Department of Orthopedic Surgery, Yokohama City University School of Medicine, Japan.
Nihon Seikeigeka Gakkai Zasshi. 1988 Jan;62(1):85-94.
Blocks of porous hydroxyapatite (dimensions, 2 X 3 X 4 mm3; sintering temperature, 1,150 degrees C; macroporosity, 48%; pore diameter, 50-300 microns) were implanted into the intervening space between the tibial periosteum and the tibialis anterior muscle in 36 male Wistar rats at the age of 5 months. Specimens from the lower leg were obtained 1, 2, 3, 5, 8 and 12 weeks after implantation. The implants were found to adhere firmly to the tibialis anterior in the 5 and 12 week-specimens. No inflammatory reactions were seen around the implants and a layer of fibrous tissue was observed between the implanted apatite block and the muscle in all specimens. The fibrous tissue penetrated deeply into pores of the apatite block. The resistance to pulling of the interface (3 X 4 mm2) between porous hydroxyapatite and the tibialis anterior muscle was measured using a universal testing machine. The mean of the resistance to pulling was 24.7 +/- 5.1 gf/mm2 in 4 specimens of 12 weeks implantation.
将多孔羟基磷灰石块（尺寸为2×3×4立方毫米；烧结温度为1150摄氏度；大孔隙率为48%；孔径为50 - 300微米）植入36只5月龄雄性Wistar大鼠胫骨骨膜与胫骨前肌之间的间隙。在植入后1、2、3、5、8和12周获取小腿标本。在5周和12周的标本中发现植入物与胫骨前肌紧密粘连。在植入物周围未见炎症反应，且在所有标本的植入磷灰石块与肌肉之间观察到一层纤维组织。纤维组织深入到磷灰石块的孔隙中。使用万能试验机测量多孔羟基磷灰石与胫骨前肌之间界面（3×4平方毫米）的抗拉伸力。在植入12周的4个标本中，抗拉伸力的平均值为24.7±5.1克力/平方毫米。
