Wang F R
Department of Orthopaedic Surgery, Jichi Medical School, Tochigi, Japan.
Nihon Seikeigeka Gakkai Zasshi. 1990 Sep;64(9):847-59.
In order to determine the most appropriate properties for hydroxyapatite, four kinds of sintered hydroxyapatite (50-250 microns & 900 degrees C, 50-250 microns & 1,100 degrees C, 300-600 microns & 1,100 degrees C, and dense & 1,100 degrees C, pore size and sintering temperature, respectively) were implanted in the animals and studied histologically. In addition, the responses at different implantation sites were compared. The results are 1) hydroxyapatite sintered at 900 degrees C temperature showed higher osteogenic activity than that sintered at 1,100 degrees C in the early period. However, this difference disappeared with time, and at 26 weeks, there was no significant difference between the two groups. 2) hydroxyapatite with a 300-600 microns pore size demonstrated osteogenic activity superior to that with a 50-250 microns pore size. 3) implantation at the epiphysis produced higher osteogenic activity in the early period, compared to implantations at the metaphysis or diaphysis. This difference in bone ingrowth had disappeared at the 26-week.
为了确定羟基磷灰石最合适的特性，将四种烧结羟基磷灰石（分别为50 - 250微米及900摄氏度、50 - 250微米及1100摄氏度、300 - 600微米及1100摄氏度、致密及1100摄氏度，分别为孔径和烧结温度）植入动物体内并进行组织学研究。此外，还比较了不同植入部位的反应。结果如下：1）900摄氏度烧结的羟基磷灰石在早期显示出比1100摄氏度烧结的更高的成骨活性。然而，这种差异随时间消失，在26周时，两组之间无显著差异。2）孔径为300 - 600微米的羟基磷灰石表现出优于孔径为50 - 250微米的成骨活性。3）与干骺端或骨干植入相比，骨骺植入在早期产生更高的成骨活性。这种骨长入的差异在26周时消失。
