Artiran Igde Fusun, Igde Mahir, Yazici Zafer, Okur Gumusova Semra, Birinci Asuman, Sancak Recep, Ozturk Fadil
Department of Family Medicine, School of Medicine, Ondokuz Mayis University, Samsun, Turkey.
New Microbiol. 2007 Apr;30(2):109-12.
Herpes Simplex Virus Type 1 (HSV-1) is a ubiquitous pathogen. Other than known diseases, HSV-1 may have an important role in the pathogenesis of atopy by causing immortality of th2 cells. From June 1st to July 31st 2006, seventy five blood samples were collected from atopic children referred to the allergy clinic of the hospital. The bloods samples were used to detect HSV-1 IgG antibodies by Enzyme-Linked Immunosorbent Assay and Virus Neutralization Test. HSV-1 IgG antibody seroprevalence in atopic children was found high, 62.6% by Enzyme-Linked Immunosorbent Assay and 57.3% by Virus Neutralization Test. Thus Virus Neutralization Test sensitivity was 92.15% and specificity was 100% regarding to the Enzyme-Linked Immunosorbent Assay technic. Although Enzyme-Linked Immunosorbent Assay was more sensitive than Virus Neutralization Test, there was no significant difference between two technics (p > 0.05) in detecting HSV-1 IgG antibodies in serum.
单纯疱疹病毒1型（HSV-1）是一种普遍存在的病原体。除了已知疾病外，HSV-1可能通过导致Th2细胞永生在特应性疾病的发病机制中发挥重要作用。2006年6月1日至7月31日，从转诊至该医院过敏诊所的特应性儿童中采集了75份血样。这些血样用于通过酶联免疫吸附测定法（ELISA）和病毒中和试验检测HSV-1 IgG抗体。结果发现，特应性儿童中HSV-1 IgG抗体血清阳性率较高，ELISA法为62.6%，病毒中和试验法为57.3%。因此，相对于ELISA技术，病毒中和试验的灵敏度为92.15%，特异性为100%。虽然ELISA比病毒中和试验更敏感，但在检测血清中HSV-1 IgG抗体方面，两种技术之间无显著差异（p>0.05）。
