Igde Mahir, Igde Fusun Artiran, Yazici Zafer
Department of Pediatric Allergic Diseases, Maternity and Children Hospital, Samsun, Turkey.
Iran J Allergy Asthma Immunol. 2009 Sep;8(3):149-54.
This study investigated the association between HSV-1 infection and atopy by comparing seropositivity to HSV-1 in atopic children with asthma and allergic rhinitis and in non-atopic children. Totally 249 children randomly selected from the university outpatient pediatric clinics were prospectively enrolled in the study between September 1 and November 30, 2007. Serum samples were examined using the virus neutralization test (VNT) for HSV-1 Immunoglobulin G(IgG) seropositivity. Skin prick tests (SPTs) were performed to determine atopic status. The results showed that HSV-1 IgG seropositivity was significantly higher in atopic children (56.8%) with asthma and allergic rhinitis than in the age-matched non-atopic children group (30.4%) (p<0.001). Although the occurrence of atopy was higher in seropositive girls (57%) than in seropositive boys (47%), the difference was not significant (p=0.329). These results support a possible relationship between the atopic status of children with asthma and allergic rhinitis and HSV-1 infection.
本研究通过比较患有哮喘和过敏性鼻炎的特应性儿童与非特应性儿童中单纯疱疹病毒1型（HSV-1）血清阳性情况，调查HSV-1感染与特应性之间的关联。2007年9月1日至11月30日期间，从大学门诊儿科诊所随机选取249名儿童前瞻性纳入本研究。采用病毒中和试验（VNT）检测血清样本中HSV-1免疫球蛋白G（IgG）血清阳性情况。进行皮肤点刺试验（SPT）以确定特应性状态。结果显示，患有哮喘和过敏性鼻炎的特应性儿童（56.8%）中HSV-1 IgG血清阳性率显著高于年龄匹配的非特应性儿童组（30.4%）（p<0.001）。虽然血清阳性女孩（57%）的特应性发生率高于血清阳性男孩（47%），但差异无统计学意义（p=0.329）。这些结果支持患有哮喘和过敏性鼻炎的儿童特应性状态与HSV-1感染之间可能存在关联。
