Basile L A, Taylor S N, Wagner C L, Quinones L, Hollis B W
Division of Neonatology, Department of Pediatrics, Medical University of South Carolina, Charleston, SC 29425, USA.
J Perinatol. 2007 Sep;27(9):568-71. doi: 10.1038/sj.jp.7211796. Epub 2007 Jul 12.
With vitamin D deficiency as a serious public health problem, vitamin D status at birth was measured in neonates at latitude 32 degrees 72' (southeastern United States).
In umbilical cord blood, vitamin D status, demonstrated by circulating 25-hydroxyvitamin D, was measured and related to race and season of birth.
The mean+/-standard deviation of 25-hydroxyvitamin D in 100 cord blood samples was 13.5+/-8.3 ng/ml for the cohort. African-American infants, with a mean+/-standard deviation of 10.5+/-6.0 ng/ml, demonstrated significantly lower vitamin D status than Caucasian infants, with a mean+/-standard deviation of 19.5+/-9.6 ng/ml (P<0.0001). By season, the mean 25-hydroxyvitamin D level at birth in November-March compared to April-October was 11.3 ng/ml lower in Caucasian infants (from 29.0 to 17.7 ng/ml) and 3 ng/ml lower in African-American infants (from 13.1 to 10.1 ng/ml).
The prevalence of vitamin D insufficiency is high in this cohort. African-American infants demonstrate significantly lower vitamin D status at birth than Caucasian infants. Seasonality, while significant in both groups, had a greater impact on the vitamin D status of Caucasian newborns.
鉴于维生素D缺乏是一个严重的公共卫生问题，对美国东南部北纬32度72分地区的新生儿出生时的维生素D状况进行了测量。
测量脐带血中循环25-羟基维生素D所显示的维生素D状况，并将其与种族和出生季节相关联。
该队列100份脐带血样本中25-羟基维生素D的均值±标准差为13.5±8.3 ng/ml。非裔美国婴儿的均值±标准差为10.5±6.0 ng/ml，其维生素D状况显著低于白人婴儿，白人婴儿的均值±标准差为19.5±9.6 ng/ml（P<0.0001）。按季节划分，11月至次年3月出生的白人婴儿出生时的平均25-羟基维生素D水平比4月至10月出生的低11.3 ng/ml（从29.0 ng/ml降至17.7 ng/ml），非裔美国婴儿低3 ng/ml（从13.1 ng/ml降至10.1 ng/ml）。
该队列中维生素D不足的患病率很高。非裔美国婴儿出生时的维生素D状况显著低于白人婴儿。季节性在两组中都有显著影响，但对白人新生儿维生素D状况的影响更大。
