Wang Huawei, Du Yiming, Wu Zhixin, Geng Haifeng, Zhu Xueping, Zhu Xiaoli
Department of Neonatology, Children's Hospital of Soochow University, Suzhou, China.
Department of Intervention, The First Affiliated Hospital of Soochow University, Suzhou, China.
Front Pediatr. 2022 May 26;10:878992. doi: 10.3389/fped.2022.878992. eCollection 2022.
This study explored the status of serum vitamin D in hospitalized full-term neonates at a tertiary hospital in eastern China.
A prospective study was conducted among 471 hospitalized full-term neonates at the Children's Hospital of Soochow University between January 1 and June 20, 2020. Perinatal clinical data, serum 25-hydroxyvitamin D (25(OH)D), laboratory examinations, serum calcium levels, and immune function were obtained and analyzed. We explored and analyzed the risk factors for vitamin D insufficiency or deficiency, and we also attempted to determine correlations between vitamin D and its influence on immunity.
The mean serum 25(OH)D was 33.65±6.07ng/ml.The prevalence of vitamin D insufficiency was 28.24%,vitamin D sufficiency was 71.76%, there was no vitamin D deficiency. The serum 25-(OH)D in singleton neonate was higher than twins or multiple infants ( = -10.918, = 0.000). The serum 25-(OH)D were higher in neonates who born in spring and summer than in winter (H = 13.443, = 0.001). The serum 25-(OH)D in appropriate for gestational age (AGA) and large for gestational age (LGA) neonates were higher than small for gestational age (SGA) (H = 7.686, = 0.021). The serum 25-(OH)D were higher in neonates whose mothers had no underlying diseases than those with certain immunological and infectious diseases (F = 12.417, = 0.000). The serum 25-(OH)D in neonates whose mothers had none or one perinatal complication were higher than those with two or more (F = 13.299, = 0.000). The neonates with eosinophils ≤5% or normal platelet counts or serum Ca ≥0.9 mmol/L have higher serum 25-(OH)D. Neonates born in winter were at risk for vitamin D insufficiency, and the incidence of infectious pneumonia, sepsis, cytomegalovirus infection, and hypocalcemia in the vitamin D insufficiency group were higher than sufficiency group ( < 0.05). The serum CD3+, CD3+CD4+, and IgA levels in vitamin D sufficiency neonates were significantly higher than those in insufficiency group ( < 0.05).
The prevalence of vitamin D insufficiency was 28.24%, and birth in winter was a risk factor for vitamin D insufficiency in hospitalized full-term neonates in Suzhou area. Neonates with infectious pneumonia, sepsis, cytomegalovirus infection, and hypocalcemia exhibited a high risk of vitamin D insufficiency. The serum CD3, CD3CD4, and IgA levels in neonates with vitamin D insufficiency were lower.
本研究探讨中国东部一家三级医院住院足月儿血清维生素D的状况。
2020年1月1日至6月20日，在苏州大学附属儿童医院对471例住院足月儿进行了一项前瞻性研究。获取并分析围产期临床资料、血清25-羟维生素D（25(OH)D）、实验室检查、血清钙水平和免疫功能。我们探讨并分析了维生素D不足或缺乏的危险因素，还试图确定维生素D与其对免疫影响之间的相关性。
血清25(OH)D的平均值为33.65±6.07ng/ml。维生素D不足的患病率为28.24%，维生素D充足率为71.76%，无维生素D缺乏情况。单胎新生儿的血清25-(OH)D高于双胎或多胎婴儿（ = -10.918， = 0.000）。春季和夏季出生的新生儿血清25-(OH)D高于冬季出生的新生儿（H = 13.443， = 0.001）。适于胎龄（AGA）和大于胎龄（LGA）的新生儿血清25-(OH)D高于小于胎龄（SGA）的新生儿（H = 7.686， = 0.021）。母亲无基础疾病的新生儿血清25-(OH)D高于患有某些免疫和感染性疾病的新生儿（F = 12.417， = 0.000）。母亲无或有一项围产期并发症的新生儿血清25-(OH)D高于有两项或更多项围产期并发症的新生儿（F = 13.299， = 0.000）。嗜酸性粒细胞≤5%或血小板计数正常或血清钙≥0.9 mmol/L的新生儿血清25-(OH)D较高。冬季出生的新生儿有维生素D不足的风险，维生素D不足组的感染性肺炎、败血症、巨细胞病毒感染和低钙血症的发生率高于充足组（ < 0.05）。维生素D充足的新生儿血清CD3+、CD3+CD4+和IgA水平显著高于不足组（ < 0.05）。
维生素D不足的患病率为28.24%，冬季出生是苏州地区住院足月儿维生素D不足的一个危险因素。患有感染性肺炎、败血症、巨细胞病毒感染和低钙血症的新生儿维生素D不足风险较高。维生素D不足的新生儿血清CD3、CD3CD4和IgA水平较低。
