Iranshahi Mehrdad, Shaki Fatemeh, Mashlab Ali, Porzel Andrea, Wessjohann Ludger A
Department of Pharmacognosy and Biotechnology, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
J Nat Prod. 2007 Aug;70(8):1240-3. doi: 10.1021/np070043u. Epub 2007 Jul 11.
Three new sesquiterpene derivatives, kopetdaghins A-C (1-3), one known prenylated coumarin (7), and two known steroid glucosides, sitosterol 3-O-glucoside and stigmasterol 3-O-glucoside, were isolated from the aerial parts of Dorema kopetdaghense. In addition, two new sesquiterpene derivatives, kopetdaghin D (4) and kopetdaghin E (5), together with kopetdaghins A-C and one known sesquiterpene coumarin (6), were isolated from the roots of the plant. The structures of these compounds were elucidated by various 1D and 2D NMR techniques as well as high-resolution positive-ion ESIMS.
从科佩特达格独活（Dorema kopetdaghense）的地上部分分离出三种新的倍半萜衍生物，即科佩特达格素A-C（1-3）、一种已知的异戊烯基香豆素（7）以及两种已知的甾体糖苷，即β-谷甾醇3-O-葡萄糖苷和豆甾醇3-O-葡萄糖苷。此外，从该植物的根部分离出两种新的倍半萜衍生物，即科佩特达格素D（4）和科佩特达格素E（5），以及科佩特达格素A-C和一种已知的倍半萜香豆素（6）。这些化合物的结构通过各种一维和二维核磁共振技术以及高分辨率正离子电喷雾电离质谱法得以阐明。
