Noormohammadi Amir H, Hemmatzadeh Farhid, Whithear Kevin G
School of Veterinary Science, The University of Melbourne, Victoria, Australia.
Avian Dis. 2007 Jun;51(2):550-4. doi: 10.1637/0005-2086(2007)51[550:SAEOTM]2.0.CO;2.
The live, attenuated, temperature-sensitive Mycoplasma synoviae (MS) vaccine strain MS-H is used to control virulent MS infection in commercial chicken flocks. However, the safety of this vaccine and its potential to prevent disease in turkeys have not been investigated. In this study, MS-H was shown to colonize the upper respiratory system and to induce an antibody response in turkeys but, even at the maximum release dose, was not found to cause air sac, joint, or tracheal lesions typical of wild-type MS infection. Histopathologic examinations of the vaccinated turkeys after exposure to a virulent MS challenge revealed that administration of the vaccine by aerosol, but not eye drop, at the dose recommended for chickens protected the birds against microscopic lesions and colonization of the virulent MS in trachea. It is concluded that MS-H vaccine is safe for use in turkeys and, when used as aerosol at the dose recommended for commercial chickens, can protect turkeys against tracheal lesions caused by a wild-type MS strain.
减毒活的温度敏感型鸡滑液支原体（MS）疫苗株MS - H用于控制商品鸡群中强毒MS感染。然而，这种疫苗的安全性及其预防火鸡疾病的潜力尚未得到研究。在本研究中，MS - H被证明能定殖于火鸡的上呼吸道并诱导抗体反应，但即使在最大释放剂量下，也未发现其会引起野生型MS感染典型的气囊、关节或气管病变。对接种疫苗的火鸡进行强毒MS攻击后的组织病理学检查显示，按照推荐给鸡的剂量通过气溶胶而非滴眼方式接种疫苗，可保护火鸡免受微观病变以及强毒MS在气管中的定殖。结论是，MS - H疫苗用于火鸡是安全的，并且当按照推荐给商品鸡的剂量以气溶胶形式使用时，可保护火鸡免受野生型MS菌株引起的气管病变。
