Liao Shang-Gao, Yang Sheng-Ping, Yuan Tao, Zhang Chuan-Rui, Chen Hua-Dong, Wu Yan, Xu You-Kai, Yue Jian-Min
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai, 201203, People's Republic of China.
J Nat Prod. 2007 Aug;70(8):1268-73. doi: 10.1021/np070146c. Epub 2007 Jul 12.
Three new norlimonoids, toonaciliatins A (1), F (6), and G (7), four new limonoids, toonaciliatins B-E (2-5), and five known compounds, 5alpha,6beta,8alpha-trihydroxy-28-norisotoonafolin (8), toonaciliatins H (9) and I (10), febrifugin (11), and khayasin T (12), were isolated from the leaves and stems of Toona ciliata. Compounds 1-3 have an unusual 1-en-3-one system with a 1,11-oxygen bridge, limonoids 11 and 12 have a mexicanolide-type structural frame, and others are typical A,B-seco- (4, 5, 9, and 10) or B-seco-29-nor- (3, 6, 7, and 8) limonoids. Toonaciliatins H (9) and I (10) were obtained for the first time as natural products. The structures were established by extensive spectroscopic methods, particularly 1D and 2D NMR techniques.
从红椿的叶和茎中分离得到了3个新的降柠檬苦素类化合物，即香椿素A（1）、F（6）和G（7），4个新的柠檬苦素类化合物，即香椿素B - E（2 - 5），以及5个已知化合物，5α,6β,8α - 三羟基 - 28 - 降异东印度棟醇（8）、香椿素H（9）和I（10）、退热碱（11）和卡亚辛T（12）。化合物1 - 3具有不寻常的带有1,11 - 氧桥的1 - 烯 - 3 - 酮体系，柠檬苦素11和12具有墨西哥内酯型结构框架，其他的是典型的A,B - 裂环（4、5、9和10）或B - 裂环 - 29 - 降（3、6、7和8）柠檬苦素类化合物。香椿素H（9）和I（10）首次作为天然产物获得。通过广泛的光谱方法，特别是一维和二维核磁共振技术确定了其结构。
