Wang Zhiping, Qi Lei, Song Xiaoqing
Department of Pediatrics, Shanghai Xin Hua Hospital, Shanghai, China.
Pediatr Neurol. 2007 Jul;37(1):16-20. doi: 10.1016/j.pediatrneurol.2007.03.005.
Our objective was to determine factors that influence the prognosis of cryptogenic partial seizures in children. In total, 233 patients were included in a hospital-based observational survey. Clinical characteristics of patients were reviewed and analyzed. Patients were characterized as having poor control of their seizures, or as having a > or = 50% decrease in their number of seizures. Student t test or Pearson's chi-square test were used to determine the differences between the groups with regard to clinical data. Multiple logistic regression analysis was used to investigate the independent effect of each risk factor. Complete seizure control was achieved in 71.7% of patients; improved seizure control was achieved in 13.3%; and poor seizure control was observed in 15.0%. Patients who had poor control of their seizures had a significantly younger age of onset (P = 0.03). In addition, chi-square analysis revealed that these patients had a higher seizure frequency (P < 0.001), and that seizure control was dependent on seizure type (P < 0.001). Multiple logistic regression analysis revealed that an initial seizure frequency of >3 per month (odds ratio [OR], 3.07; 95% confidence interval [CI], 1.37-6.88), age of onset (OR, 1.14; 95% CI, 1.0-1.31), and seizure type (OR, 0.48; 95% CI, 0.22-1.01) were predictors of poor seizure control.
我们的目标是确定影响儿童隐源性部分性癫痫预后的因素。总共233例患者纳入了一项基于医院的观察性调查。对患者的临床特征进行了回顾和分析。将患者分为癫痫发作控制不佳组，或癫痫发作次数减少≥50%组。采用Student t检验或Pearson卡方检验来确定两组临床数据的差异。采用多因素logistic回归分析来研究各危险因素的独立作用。71.7%的患者实现了癫痫发作完全控制；13.3%的患者癫痫发作控制情况有所改善；15.0%的患者癫痫发作控制不佳。癫痫发作控制不佳的患者起病年龄显著更小（P = 0.03）。此外，卡方分析显示，这些患者癫痫发作频率更高（P < 0.001），且癫痫发作控制情况取决于癫痫发作类型（P < 0.001）。多因素logistic回归分析显示，每月初始癫痫发作频率>3次（比值比[OR]，3.07；95%置信区间[CI]，1.37 - 6.88）、起病年龄（OR，1.14；95% CI，1.0 - 1.31）和癫痫发作类型（OR，0.48；95% CI，0.22 - 1.01）是癫痫发作控制不佳的预测因素。
