Antiproliferative activity of Citrus juices and HPLC evaluation of their flavonoid composition.

作者信息

Camarda Lorenzo, Di Stefano Vita, Del Bosco Sergio Fatta, Schillaci Domenico

机构信息

Dipartimento di Chimica e Tecnologie Farmaceutiche, Università degli Studi di Palermo, via Archirafi 32, 90123, Palermo, Italy.

出版信息

Fitoterapia. 2007 Sep;78(6):426-9. doi: 10.1016/j.fitote.2007.02.020. Epub 2007 May 23.

The antiproliferative activity of fresh fruit juices extracted from Citrus sinensis (cv. Washington Navel and cv. Sanguinello), C. deliciosa cv. Avana, C. clementina cv. Nules, C. aurantium subsp. myrtifolia , was evaluated against K562 (human chronic myelogenous leukemia), HL-60 (human leukemia) and MCF-7 (human breast adenocarcinoma) cell lines. All the juices tested showed antiproliferative activity. Moreover, the pattern of the main flavanone compounds in the juices has been determined by HPLC analysis.