Zou Jian, Mi Yi, Chen Wenliang, Liu Qunfang, Wang Jian, Lou Liguang, Zhao Weimin
Department of Natural Products Chemistry, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P. R. China.
Planta Med. 2006 May;72(6):533-8. doi: 10.1055/s-2006-931559.
Eleven compounds have been identified from the whole plants of Syzygium levinei (Myrtaceae) on the basis of spectroscopic analysis and chemical methods. Among these compounds, (Z)-1-(2,6-dihydroxy-4-methoxyphenyl)-oct-5-en-1-one (1), (3 E,7 Z)-1-(2,6-dihydroxy-4-methoxyphenyl)-deca-3,7-dien-1-one (2), and 1-(2-O-beta-D-glucopyranosyl-5,6-dihydroxy-4-methoxyphenyl)-octan-1-one (3) were characterized as new alkyl phloroglucinol derivatives, and 1-(2,6-dihydroxy-4-methoxyphenyl)-hexan-1-one (4) was identified as a new natural product. Compounds 1, 2, and 4 were found to inhibit the proliferation of leukemia K562 and HL-60 cells and also to induce the differentiation of K562 cells as determined by the appearance of matured morphology and the increase in the intracellular hemoglobin level.
通过光谱分析和化学方法，已从水翁（桃金娘科）全株中鉴定出11种化合物。在这些化合物中，(Z)-1-(2,6-二羟基-4-甲氧基苯基)-辛-5-烯-1-酮（1）、(3E,7Z)-1-(2,6-二羟基-4-甲氧基苯基)-癸-3,7-二烯-1-酮（2）和1-(2-O-β-D-吡喃葡萄糖基-5,6-二羟基-4-甲氧基苯基)-辛烷-1-酮（3）被鉴定为新的烷基间苯三酚衍生物，1-(2,6-二羟基-4-甲氧基苯基)-己烷-1-酮（4）被鉴定为新的天然产物。通过成熟形态的出现和细胞内血红蛋白水平的增加确定，发现化合物1、2和4可抑制白血病K562和HL-60细胞的增殖，并诱导K562细胞分化。
