Nie Jing, Zhu Hong-Wei, Cui Han-Feng, Hua Ming-Qing, Ma Jun-An
Department of Chemistry, School of Science, Tianjin University, Tianjin 300072, China.
Org Lett. 2007 Aug 2;9(16):3053-6. doi: 10.1021/ol071114j. Epub 2007 Jul 13.
A new catalytic stereoselective tandem transformation via Nazarov cyclization/electrophilic fluorination has been accomplished. This sequence is efficiently catalyzed by a Cu(II) complex to afford fluorine-containing 1-indanone derivatives with two new stereocenters with high diastereoselectivity (trans/cis up to 49/1). Three examples of catalytic enantioselective tandem transformation are presented.
通过纳扎罗夫环化/亲电氟化实现了一种新的催化立体选择性串联转化。该反应序列由铜（II）配合物有效催化，以高非对映选择性（反式/顺式高达49/1）得到含有两个新立体中心的含氟1-茚酮衍生物。给出了三个催化对映选择性串联转化的实例。
