动物发育中的平面极性原则。
Principles of planar polarity in animal development.
机构信息
Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
出版信息
Development. 2011 May;138(10):1877-92. doi: 10.1242/dev.054080.
Abstract
Planar polarity describes the coordinated polarisation of cells or structures in the plane of a tissue. The patterning mechanisms that underlie planar polarity are well characterised in Drosophila, where many events are regulated by two pathways: the 'core' planar polarity complex and the Fat/Dachsous system. Components of both pathways also function in vertebrates and are implicated in diverse morphogenetic processes, some of which self-evidently involve planar polarisation and some of which do not. Here, we review the molecular mechanisms and cellular consequences of planar polarisation in diverse contexts, seeking to identify the common principles across the animal kingdom.
摘要
平面极性描述了组织平面中细胞或结构的协调极化。平面极性的模式形成机制在果蝇中得到了很好的描述，其中许多事件受两条途径调控：“核心”平面极性复合物和 Fat/Dachsous 系统。这两条途径的成分也在脊椎动物中发挥作用，并参与多种形态发生过程，其中一些显然涉及平面极性，而另一些则不涉及。在这里，我们综述了不同背景下平面极性的分子机制和细胞后果，试图确定整个动物界的共同原则。
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本文引用的文献
1
Cell Migration and Induction in the Development of the Surface Ectodermal Pattern of the Xenopus laevis Tadpole: (Xenopus/ciliated cell/hatching gland/cement gland/ectodermal differentiation).非洲爪蟾蝌蚪表面外胚层模式发育中的细胞迁移与诱导：（非洲爪蟾/纤毛细胞/孵化腺/黏着腺/外胚层分化）
Dev Growth Differ. 1992 Feb;34(1):51-59. doi: 10.1111/j.1440-169X.1992.00051.x.
2
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Rouxs Arch Dev Biol. 1987 Jul;196(5):286-289. doi: 10.1007/BF00395951.
3
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