Perry Stephanie M, Gupta Rishi R, Van Kleunen Jonathan, Ramsey Matthew L, Soslowsky Louis J, Glaser David L
McKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA.
J Shoulder Elbow Surg. 2007 Sep-Oct;16(5 Suppl):S179-83. doi: 10.1016/j.jse.2007.03.009. Epub 2007 Jul 12.
Augmentation materials for rotator cuff tears, such as small intestine submucosa (SIS), have been used with the goal of improving outcome. Knowledge is limited on the use of SIS in animal models of acute and chronic rotator cuff tears. We hypothesized that the use of SIS in the surgical management of full thickness supraspinatus tears would improve histologic and biomechanical properties. Results show temporal improvements in several histologic parameters. Both acute and chronic injuries repaired with SIS have similar and increased mechanical properties respectively, compared to those repaired without SIS. In general, acute repairs with SIS were comparable to acute repairs without SIS. In chronic repairs, the use of SIS significantly reduced the cross sectional area of the healing tendon and increased the modulus. These results provide information on the use of SIS for rotator cuff repairs.
肩袖撕裂的增强材料，如小肠黏膜下层（SIS），已被用于改善治疗效果。关于SIS在急性和慢性肩袖撕裂动物模型中的应用，相关知识有限。我们假设，在全层冈上肌撕裂的手术治疗中使用SIS将改善组织学和生物力学特性。结果显示，几个组织学参数随时间有所改善。与未使用SIS修复的相比，使用SIS修复的急性和慢性损伤分别具有相似且增强的力学性能。总体而言，使用SIS的急性修复与未使用SIS的急性修复相当。在慢性修复中，使用SIS显著减小了愈合肌腱的横截面积并提高了模量。这些结果为SIS在肩袖修复中的应用提供了信息。
