Huang Mei-Liang, Liao Wen-Ling, Ho Mei-Shang
College of Public Health, National Taiwan University, Taipei, Taiwan.
Vaccine. 2007 Aug 21;25(34):6326-33. doi: 10.1016/j.vaccine.2007.06.022. Epub 2007 Jun 29.
A serosurvey targeting Hepatitis B virus (HBV)-vaccinated children born between 1986 and 1998 was conducted in 2001 in remote Taiwanese villages where a 1993 serosurvey indicated high vaccine failure. The HBV S antigen (HBsAg) seropositive rate among vaccinees of 3-6-year-old children in 2001 was significantly lower than that of 1993 and was higher among children who had a delayed vaccination schedule and received the plasma-derived vaccine. Vaccine escape variants were more prevalent among recipients of recombinant HBV vaccine residing in Hualien. Our study highlights the importance of continued monitoring of vaccinees for incidence of HBV infection in order to refine future vaccination policy.
2001年，在台湾偏远村庄针对1986年至1998年出生且接种过乙肝病毒（HBV）疫苗的儿童开展了一项血清学调查，1993年的一项血清学调查显示这些村庄疫苗接种失败率很高。2001年3至6岁接种疫苗儿童中HBV S抗原（HBsAg）血清阳性率显著低于1993年，且接种程序延迟并接种血浆源性疫苗的儿童中该比率更高。疫苗逃逸变异株在花莲接受重组乙肝疫苗接种者中更为普遍。我们的研究强调持续监测疫苗接种者HBV感染发生率对于完善未来疫苗接种政策的重要性。
