Exley Christopher, Charles Lisa M, Barr Lester, Martin Claire, Polwart Anthony, Darbre Philippa D
Birchall Centre for Inorganic Chemistry and Materials Science, Lennard-Jones Laboratories, Keele University, Staffordshire ST5 5BG, UK.
J Inorg Biochem. 2007 Sep;101(9):1344-6. doi: 10.1016/j.jinorgbio.2007.06.005. Epub 2007 Jun 12.
Aluminium is omnipresent in everyday life and increased exposure is resulting in a burgeoning body burden of this non-essential metal. Personal care products are potential contributors to the body burden of aluminium and recent evidence has linked breast cancer with aluminium-based antiperspirants. We have used graphite furnace atomic absorption spectrometry (GFAAS) to measure the aluminium content in breast biopsies obtained following mastectomies. The aluminium content of breast tissue and breast tissue fat were in the range 4-437 nmol/g dry wt. and 3-192 nmol/g oil, respectively. The aluminium content of breast tissue in the outer regions (axilla and lateral) was significantly higher (P=0.033) than the inner regions (middle and medial) of the breast. Whether differences in the regional distribution of aluminium in the breast are related to the known higher incidence of tumours in the outer upper quadrant of the breast remains to be ascertained.
铝在日常生活中无处不在，接触量的增加导致这种非必需金属在人体内的负担不断加重。个人护理产品可能是铝在人体负担中的来源，最近有证据表明乳腺癌与铝基止汗剂有关。我们使用石墨炉原子吸收光谱法（GFAAS）测量了乳房切除术后获得的乳房活检组织中的铝含量。乳房组织和乳房组织脂肪中的铝含量分别在4 - 437 nmol/g干重和3 - 192 nmol/g油的范围内。乳房外部区域（腋窝和外侧）的乳房组织铝含量显著高于乳房内部区域（中部和内侧）（P = 0.033）。乳房中铝的区域分布差异是否与乳房外上象限已知的较高肿瘤发病率有关，仍有待确定。
