使用腋下美容产品与乳腺癌风险的关系：一项病例对照研究。
Use of Underarm Cosmetic Products in Relation to Risk of Breast Cancer: A Case-Control Study.
机构信息
Department of Medical Statistics, Informatics and Health Economics, Medical University of Innsbruck, Austria.
Division of Clinical Biochemistry, Biocenter, Medical University of Innsbruck, Austria.
出版信息
EBioMedicine. 2017 Jul;21:79-85. doi: 10.1016/j.ebiom.2017.06.005. Epub 2017 Jun 6.
BACKGROUND
Previous studies on breast cancer (BC), underarm cosmetic products (UCP) and aluminum salts have shown conflicting results. We conducted a 1:1 age-matched case-control study to investigate the risk for BC in relation to self-reported UCP application.
METHODS
Self-reported history of UCP use was compared between 209 female BC patients (cases) and 209 healthy controls. Aluminum concentration in breast tissue was measured in 100 cases and 52 controls. Multivariable conditional logistic regression analysis was performed to estimate odds ratios (ORs) with 95% confidence intervals (CIs), adjusting for established BC risk factors.
FINDINGS
Use of UCP was significantly associated with risk of BC (p=0.036). The risk for BC increased by an OR of 3.88 (95% CI 1.03-14.66) in women who reported using UCP's several times daily starting at an age earlier than 30years. Aluminum in breast tissue was found in both cases and controls and was significantly associated to self-reported UCP use (p=0.009). Median (interquartile) aluminum concentrations were significantly higher (p=0.001) in cases than in controls (5.8, 2.3-12.9 versus 3.8, 2.5-5.8nmol/g).
INTERPRETATION
Frequent use of UCPs may lead to an accumulation of aluminum in breast tissue. More than daily use of UCPs at younger ages may increase the risk of BC.
背景
先前关于乳腺癌（BC）、腋下美容产品（UCP）和铝盐的研究结果相互矛盾。我们进行了一项 1:1 年龄匹配的病例对照研究，以调查与自我报告的 UCP 应用相关的 BC 风险。
方法
比较了 209 名女性 BC 患者（病例）和 209 名健康对照者的 UCP 使用史。在 100 例病例和 52 例对照中测量了乳房组织中的铝浓度。使用多变量条件逻辑回归分析来估计比值比（OR）及其 95%置信区间（CI），调整了已确定的 BC 风险因素。
结果
UCP 的使用与 BC 风险显著相关（p=0.036）。在年龄小于 30 岁时开始每天多次使用 UCP 的女性中，BC 的风险增加了 3.88 倍（95%CI 1.03-14.66）。在病例和对照者中均发现了乳房组织中的铝，且与自我报告的 UCP 使用显著相关（p=0.009）。病例组和对照组的中位数（四分位间距）铝浓度均显著较高（p=0.001）（5.8，2.3-12.9 与 3.8，2.5-5.8nmol/g）。
解释
频繁使用 UCP 可能导致铝在乳房组织中蓄积。年轻时每天使用 UCP 超过一次可能会增加 BC 的风险。
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