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人类I型嗜T细胞淋巴细胞病毒（HTLV-I）转录激活因子Tax与特异性结合HTLV-I增强子中21个碱基对重复序列的细胞因子之间的相互作用。

Interaction of the human T-cell lymphotrophic virus type I (HTLV-I) transcriptional activator Tax with cellular factors that bind specifically to the 21-base-pair repeats in the HTLV-I enhancer.

作者信息

Zhao L J, Giam C Z

机构信息

Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106.

出版信息

Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11445-9. doi: 10.1073/pnas.88.24.11445.

DOI:10.1073/pnas.88.24.11445
PMID:1763059
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC53152/
Abstract

The human T-cell lymphotrophic virus type I (HTLV-I) Tax protein activates transcription from three 21-base-pair (bp) repeat sequences in the viral enhancer. Using gel electrophoretic mobility-shift assays, we now show that Tax interacts directly with the nuclear proteins, Tax activation factors (TAFs), that bind the 21-bp repeats. This interaction is demonstrated by decreased electrophoretic mobilities of the TAFs-21-bp-repeats complexes upon supply of Tax exogenously. Formation of the TAFs-21-bp-repeats and Tax-TAFs-21-bp-repeats complexes correlates with in vivo transactivation by Tax. Furthermore, interaction of Tax with TAFs enhances their binding to the 21-bp repeats. These data indicate that trans-activation by Tax is most likely mediated by interaction of Tax with TAFs.

摘要

人类I型嗜T细胞淋巴病毒（HTLV-I）的Tax蛋白可激活病毒增强子中三个21碱基对（bp）重复序列的转录。利用凝胶电泳迁移率变动分析，我们现在表明Tax可直接与结合21-bp重复序列的核蛋白——Tax激活因子（TAFs）相互作用。这种相互作用通过外源提供Tax时TAFs-21-bp重复序列复合物电泳迁移率降低得以证明。TAFs-21-bp重复序列复合物和Tax-TAFs-21-bp重复序列复合物的形成与Tax在体内的反式激活相关。此外，Tax与TAFs的相互作用增强了它们与21-bp重复序列的结合。这些数据表明，Tax的反式激活很可能是由Tax与TAFs的相互作用介导的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f050/53152/eddbbd57e3b3/pnas01074-0477-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f050/53152/8b6e01134abe/pnas01074-0475-a.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f050/53152/9e0c4547a233/pnas01074-0476-b.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f050/53152/8126b7b423e3/pnas01074-0477-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f050/53152/eddbbd57e3b3/pnas01074-0477-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f050/53152/8b6e01134abe/pnas01074-0475-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f050/53152/301536e03a93/pnas01074-0475-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f050/53152/99e5e9245621/pnas01074-0475-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f050/53152/559818b20fd2/pnas01074-0476-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f050/53152/9e0c4547a233/pnas01074-0476-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f050/53152/b7151642fb18/pnas01074-0476-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f050/53152/aed37ff8be56/pnas01074-0477-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f050/53152/8126b7b423e3/pnas01074-0477-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f050/53152/eddbbd57e3b3/pnas01074-0477-c.jpg

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Trans-acting transcriptional activation of the long terminal repeat of human T lymphotropic viruses in infected cells.人嗜T淋巴细胞病毒长末端重复序列在受感染细胞中的反式作用转录激活
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Requirement of multiple copies of a 21-nucleotide sequence in the U3 regions of human T-cell leukemia virus type I and type II long terminal repeats for trans-acting activation of transcription.人嗜T淋巴细胞病毒I型和II型长末端重复序列U3区域中一个21核苷酸序列的多个拷贝对于转录反式激活的需求。
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Expression of the complete human T-cell leukemia virus type I pX coding sequence as a functional protein in Escherichia coli.完整的人I型T细胞白血病病毒pX编码序列在大肠杆菌中表达为功能性蛋白。
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