Leeb K, Parker L, Eikelboom R
Psychology Department, Wilfrid Laurier University, Waterloo, Ontario, Canada.
Pharmacol Biochem Behav. 1991 Aug;39(4):895-901. doi: 10.1016/0091-3057(91)90050-c.
The ability of the neuroleptic agent, pimozide, to modify sucrose palatability was assessed using three 10-min taste reactivity test sessions. Pimozide was found to suppress the ingestive response of tongue protrusions, but enhance the mildly ingestive/neutral response of mouth movements elicited by an intraoral infusion of sucrose solution. Since the pattern of taste reactivity responding shifted from highly ingestive to mildly ingestive/neutral, our results suggest that pimozide pretreatment reduces the palatability of sucrose solution. The temporal pattern of the modification of these taste reactivity responses was predicted by the Anhedonia Hypothesis.
使用三个10分钟的味觉反应测试环节评估了抗精神病药物匹莫齐特改变蔗糖适口性的能力。结果发现，匹莫齐特可抑制伸舌的摄取反应，但增强口腔内注入蔗糖溶液所引发的轻度摄取/中性的口部运动反应。由于味觉反应模式从高度摄取转变为轻度摄取/中性，我们的结果表明，匹莫齐特预处理降低了蔗糖溶液的适口性。快感缺失假说预测了这些味觉反应改变的时间模式。
