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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

De Saint Hilaire-Kafi Z, Vallet P G, Gaillard J M

Neurobiologie des Régulations, Collège de France, Paris.

Prog Neuropsychopharmacol Biol Psychiatry. 1991;15(6):817-23. doi: 10.1016/0278-5846(91)90010-x.

Caerulein, an analogue of cholecystokinin (CCK-8), like CCK-8, has been shown to produce hypnotic effects similar to those of benzodiazepine (flunitrazepam). 2. Proglumide antagonizes the action of CCK-8 and of its analogue. 3. The aim of the present study was to demonstrate whether proglumide would affect the potent hypnotic action of flunitrazepam in rats. 4. The association of proglumide with flunitrazepam suppress the increase of total sleep time and slow wave sleep seen after flunitrazepam alone. Proglumide alone has no effect on sleep stages. The authors report here for the first time that the hypnotic action of flunitrazepam is antagonized by proglumide in rat.

雨蛙肽是胆囊收缩素（CCK - 8）的类似物，与CCK - 8一样，已被证明能产生与苯二氮䓬（氟硝西泮）类似的催眠作用。2. 丙谷胺可拮抗CCK - 8及其类似物的作用。3. 本研究的目的是证明丙谷胺是否会影响氟硝西泮对大鼠的强效催眠作用。4. 丙谷胺与氟硝西泮联合使用会抑制单独使用氟硝西泮后出现的总睡眠时间增加和慢波睡眠增加。单独使用丙谷胺对睡眠阶段没有影响。作者在此首次报道，丙谷胺可拮抗氟硝西泮对大鼠的催眠作用。

De Saint Hilaire-Kafi Z, Vallet P G, Gaillard J M

Neurobiologie des Régulations, Collège de France, Paris.

Prog Neuropsychopharmacol Biol Psychiatry. 1991;15(6):817-23. doi: 10.1016/0278-5846(91)90010-x.

Caerulein, an analogue of cholecystokinin (CCK-8), like CCK-8, has been shown to produce hypnotic effects similar to those of benzodiazepine (flunitrazepam). 2. Proglumide antagonizes the action of CCK-8 and of its analogue. 3. The aim of the present study was to demonstrate whether proglumide would affect the potent hypnotic action of flunitrazepam in rats. 4. The association of proglumide with flunitrazepam suppress the increase of total sleep time and slow wave sleep seen after flunitrazepam alone. Proglumide alone has no effect on sleep stages. The authors report here for the first time that the hypnotic action of flunitrazepam is antagonized by proglumide in rat.

雨蛙肽是胆囊收缩素（CCK - 8）的类似物，与CCK - 8一样，已被证明能产生与苯二氮䓬（氟硝西泮）类似的催眠作用。2. 丙谷胺可拮抗CCK - 8及其类似物的作用。3. 本研究的目的是证明丙谷胺是否会影响氟硝西泮对大鼠的强效催眠作用。4. 丙谷胺与氟硝西泮联合使用会抑制单独使用氟硝西泮后出现的总睡眠时间增加和慢波睡眠增加。单独使用丙谷胺对睡眠阶段没有影响。作者在此首次报道，丙谷胺可拮抗氟硝西泮对大鼠的催眠作用。