Lacy P E, Hegre O D, Gerasimidi-Vazeou A, Gentile F T, Dionne K E
Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110.
Science. 1991 Dec 20;254(5039):1782-4. doi: 10.1126/science.1763328.
The goal of islet transplantation in human diabetes is to maintain the islet grafts in the recipients without the use of immunosuppression. One approach is to encapsulate the donor islets in permselective membranes. Hollow fibers fabricated from an acrylic copolymer were used to encapsulate small numbers of rat islets that were immobilized in an alginate hydrogel for transplantation in diabetic mice. The fibers were biocompatible, prevented rejection, and maintained normoglycemia when transplanted intraperitoneally; hyperglycemia returned when the fibers were removed at 60 days. Normoglycemia was also maintained by subcutaneous implants that had an appropriately constructed outer surface on the fibers.
人类糖尿病胰岛移植的目标是在不使用免疫抑制的情况下，使胰岛移植物在受体中得以维持。一种方法是将供体胰岛封装在具有选择透过性的膜中。由丙烯酸共聚物制成的中空纤维被用于封装少量固定在藻酸盐水凝胶中的大鼠胰岛，用于移植到糖尿病小鼠体内。这些纤维具有生物相容性，可防止排斥反应，并且当经腹腔移植时能维持血糖正常；在60天时取出纤维后，血糖又恢复为高血糖状态。通过在纤维上具有适当构建的外表面的皮下植入物也能维持血糖正常。
