Vercruysse J, Schetters T P M, Knox D P, Willadsen P, Claerebout E
Ghent University, Faculty of Veterinary Medicine, Department of Virology, Parasitology and Immunology, Salisburylaan 133, B9820 Merelbeke, Belgium.
Rev Sci Tech. 2007 Apr;26(1):105-15.
Antiparasitic drugs have been used successfully to control parasitic diseases in animals for many years, as they are safe, cheap and effective against a broad spectrum of parasites. One drawback of this success appears to be the emergence of drug resistance in many target parasites. Moreover, issues of residues in the food chain and environment have arisen, which threaten their sustained use. Control methods in which vaccines would have a central role provide attractive alternatives. However, while attenuated parasite vaccines have been successful, sub-unit vaccines are still rare. The advent of new techniques in molecular biology allows the elucidation of entire parasite genomes and the identification of individual genes. It is envisaged that a further understanding of parasite genes and the role of their products in parasite biology may lead to the identification of useful antigens, which could then be produced in recombinant systems. However, for this aim to be realised, continued investment in basic research on the complex interplay between parasite and host will be necessary.
多年来，抗寄生虫药物已成功用于控制动物的寄生虫病，因为它们安全、廉价且对多种寄生虫有效。这种成功带来的一个缺点似乎是许多目标寄生虫出现了耐药性。此外，食物链和环境中的残留问题也已出现，这威胁到它们的持续使用。以疫苗为核心的控制方法提供了有吸引力的替代方案。然而，虽然减毒寄生虫疫苗已取得成功，但亚单位疫苗仍然很少见。分子生物学新技术的出现使得能够阐明整个寄生虫基因组并鉴定单个基因。据设想，进一步了解寄生虫基因及其产物在寄生虫生物学中的作用可能会导致鉴定出有用的抗原，然后可以在重组系统中生产这些抗原。然而，为了实现这一目标，有必要继续投资于关于寄生虫与宿主之间复杂相互作用的基础研究。
