纳米颗粒用于抗寄生虫药物递送。
Nanoparticles for antiparasitic drug delivery.
机构信息
National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Wuhan, China.
MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan, China.
出版信息
Drug Deliv. 2019 Dec;26(1):1206-1221. doi: 10.1080/10717544.2019.1692968.
As an emerging novel drug carrier, nanoparticles provide a promising way for effective treatment of parasitic diseases by overcoming the shortcomings of low bioavailability, poor cellular permeability, nonspecific distribution and rapid elimination of antiparasitic drugs from the body. In recent years, some kinds of ideal nanocarriers have been developed for antiparasitic drug delivery. In this review, the progress of the enhanced antiparasitic effects of different nanoparticles payload and their influencing factors were firstly summarized. Secondly, the transport and disposition process in the body were reviewed. Finally, the challenges and prospects of nanoparticles for antiparasitic drug delivery were proposed. This review will help scholars to understand the development trend of nanoparticles in the treatment of parasitic diseases and explore strategies in the development of more efficient nanocarriers to overcome the difficulty in the treatment of parasite infections in the future.
作为一种新兴的新型药物载体，纳米颗粒通过克服抗寄生虫药物生物利用度低、细胞通透性差、非特异性分布和体内快速消除等缺点，为有效治疗寄生虫病提供了一种有前途的方法。近年来，已经开发出一些理想的纳米载体用于抗寄生虫药物递送。在本文中，首先总结了不同纳米颗粒负载物增强抗寄生虫作用的进展及其影响因素。其次，综述了体内的转运和处置过程。最后，提出了纳米颗粒用于抗寄生虫药物传递的挑战和前景。本文综述将有助于学者了解纳米颗粒在寄生虫病治疗中的发展趋势，并探讨开发更有效的纳米载体的策略，以克服未来寄生虫感染治疗的困难。
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