McCarley Cynthia, Hanneman Sandra K, Padhye Nikhil, Smolensky Michael H
Division of Nursing, Stephen F. Austin State University, PO Box6156, SFA Station, Nacogdoches, TX 75962-6156, USA.
Biol Res Nurs. 2007 Jul;9(1):8-20. doi: 10.1177/1099800407303501.
The purposes of this pilot study are to describe the 24-hr patterns of dyspnea, fatigue, and peak expiratory flow rate (PEFR) in patients with chronic obstructive pulmonary disease (COPD) and examine their interrelationships. The repeated-measures design protocol involved 10 patients with moderate to severe COPD who self-assessed dyspnea, fatigue, and PEFR five times a day for 8 days. Circadian rhythms were documented by single cosinor analysis in 40% of the participants for dyspnea, 60% for fatigue, and 60% for PEFR. The 8-day, 24-hr means of dyspnea and fatigue were moderately correlated; 70% of the sample displayed significant correlations. The means of PEFR and both dyspnea and fatigue were weakly negatively correlated. The findings suggest that circadian rhythm in lung function may not be temporally coupled with the circadian rhythm in dyspnea and fatigue in all patients and that the mean self-perceived levels of dyspnea and fatigue are moderately related.
这项初步研究的目的是描述慢性阻塞性肺疾病（COPD）患者呼吸困难、疲劳和呼气峰值流速（PEFR）的24小时模式，并研究它们之间的相互关系。重复测量设计方案涉及10例中重度COPD患者，他们在8天内每天自我评估呼吸困难、疲劳和PEFR五次。40%的参与者通过单余弦分析记录了呼吸困难的昼夜节律，60%记录了疲劳的昼夜节律，60%记录了PEFR的昼夜节律。呼吸困难和疲劳的8天24小时平均值呈中度相关；70%的样本显示出显著相关性。PEFR与呼吸困难和疲劳的平均值均呈弱负相关。研究结果表明，并非所有患者的肺功能昼夜节律都与呼吸困难和疲劳的昼夜节律在时间上相关联，并且呼吸困难和疲劳的平均自我感知水平呈中度相关。
