Moores P, Smart E
Natal Institute of Immunology, Natal Blood Transfusion Service, Durban, South Africa.
Vox Sang. 1991;61(2):122-9. doi: 10.1111/j.1423-0410.1991.tb00257.x.
Rh34 antibodies were found to have a unique, previously only partly characterised, specificity within the Rh system. No evidence was seen that they were mixtures of hrB and Hr-like antibodies, or that hrB antibodies existed independently in the natural state. The term anti-hrB applied to Rh34 antibodies after they had been partially absorbed with R2R2 red cells. Four haplotypes not expressing Rh34 antigen were identified in the present study. The prefix * has been used to indicate them in this text. They were *r's (*dCces), *Ro (*Dce), *Rou (*D(uce)) and *R(od) (category III *Dce). Red cells with partially deleted or Rh(null) phenotypes were therefore not the sole red cells compatible with anti-Rh34. R2R2 red cells, which are known to carry weak Rh34 antigen, were incompatible. Twenty-two family and mother-child studies established that the Rh:-34 haplotypes were inherited as normal Mendelian dominant characters. Anti-Rh34 was capable of recognising RH 34 dosage and of excluding some men who had been wrongly accused in disputed paternity tests.
发现Rh34抗体在Rh系统内具有独特的、此前仅部分得到表征的特异性。未发现证据表明它们是hrB和类Hr抗体的混合物，也没有证据表明hrB抗体以天然状态独立存在。在Rh34抗体用R2R2红细胞部分吸收后，将其称为抗hrB。在本研究中鉴定出四种不表达Rh34抗原的单倍型。本文中用前缀来表示它们。它们是r's（*dCces）、*Ro（*Dce）、Rou（D(uce)）和R(od)（III类Dce）。因此，具有部分缺失或Rh(null)表型的红细胞并非唯一与抗Rh34相容的红细胞。已知携带弱Rh34抗原的R2R2红细胞不相容。22项家系和母婴研究证实，Rh:-34单倍型作为正常孟德尔显性性状遗传。抗Rh34能够识别RH 34剂量，并能排除一些在有争议的亲子鉴定中被错误指控的男性。
