在三名具有D+C+c+E-e+红细胞的德国兄弟姐妹中，有两人检测到Rh33。

Rh33 in two of three German siblings with D+ C+ c+ E- e+ red cells.

作者信息

Moores P, Smart E, Sternberger J, Schneider W

机构信息

Natal Institute of Immunology, Durban, South Africa.

出版信息

Transfusion. 1991 Oct;31(8):759-61. doi: 10.1046/j.1537-2995.1991.31892023505.x.

DOI:10.1046/j.1537-2995.1991.31892023505.x

PMID:1926324

Abstract

The proposita in a German family of three siblings has D+ C+ c+ E- e+ f+ Rh: -17,19,33,34 red cells with weak C, e, f, Rh19, and Rh34 and stronger-than-usual Rh33 expression. One sibling has D+ C+ c+ E- e+ f+ Rh:17,19,33,34 red cells with weak f and ordinary-strength Rh33, and the other sibling has D+ C+ c+ E- e+ f+ Rh:17,19,-33,34 red cells. In the absence of any further family members, the proposita's unusual phenotype suggests that she has an RoHar haplotype and a "new" Rh haplotype, provisionally named R1Lisa, that encodes Rh33, normal-strength D, weak C, weak or nondemonstrable e, Rh19, and Rh34, but not Rh17. Her Rh:33 sibling may have R1 and RoHar and her Rh:-33 sibling R1 and r haplotypes.

摘要

在一个有三个兄弟姐妹的德国家庭中，先证者的红细胞为D+C+c+E - e+f+Rh: - 17,19,33,34，C、e、f、Rh19和Rh34抗原表达较弱，Rh33表达强于正常。一个兄弟姐妹的红细胞为D+C+c+E - e+f+Rh:17,19,33,34，f抗原表达较弱，Rh33强度正常；另一个兄弟姐妹的红细胞为D+C+c+E - e+f+Rh:17,19, - 33,34。由于没有其他家庭成员，先证者不寻常的表型表明她有一个RoHar单倍型和一个“新的”Rh单倍型，暂命名为R1Lisa，该单倍型编码Rh33、正常强度的D、弱C、弱或不可检测的e、Rh19和Rh34，但不编码Rh17。她的Rh:33的兄弟姐妹可能有R1和RoHar单倍型，她的Rh: - 33的兄弟姐妹可能有R1和r单倍型。