Demir Becen, Sengün Dilek, Berberoğlu Atilla
Department of Periodontology, Faculty of Dentistry, University of Hacettepe, Ankara, Turkey.
J Clin Periodontol. 2007 Aug;34(8):709-15. doi: 10.1111/j.1600-051X.2007.01108.x.
There are limited numbers of studies focused on the using of platelet-rich plasma (PRP) combined with different types of bone substitutes in intra-bony defects.
The purpose of this study was to evaluate the effect of bioactive glass graft material (BG) with and without PRP on the clinical healing of intra-bony defects.
Twenty-nine intra-bony defects were randomly treated with either PRP/BG or BG alone. Clinical parameters were recorded at baseline and repeated 9 months after surgery and surgical reentries were also performed.
The results showed that both treatment modalities were effective. Pocket depth reduction of 3.60 +/- 0.51 mm, clinical attachment gain of 3.3 +/- 1.77 mm and defect fill of 3.47 +/- 0.53 mm were noted in the PRP/BG group, with 3.29 +/- 1.68, 2.86 +/- 1.56 and 3.36 +/- 0.55 mm improvements, respectively, noted for the BG group. None of the differences between the two treatment modalities were statistically significant.
It is suggested that both PRP/BG combination and BG alone are effective in the treatment of intra-bony defects. The results also showed that using PRP with BG has no additional benefit in the reduction of pocket depth, clinical attachment gain and defect fill.
关注富血小板血浆（PRP）与不同类型骨替代物联合用于骨内缺损的研究数量有限。
本研究旨在评估含PRP和不含PRP的生物活性玻璃移植材料（BG）对骨内缺损临床愈合的影响。
29处骨内缺损被随机分为PRP/BG组或单纯BG组进行治疗。在基线时记录临床参数，并在术后9个月重复记录，同时进行手术再入路操作。
结果显示两种治疗方式均有效。PRP/BG组的牙周袋深度减少3.60±0.51mm，临床附着增加3.3±1.77mm，缺损填充3.47±0.53mm；BG组分别改善3.29±1.68mm、2.86±1.56mm和3.36±0.55mm。两种治疗方式之间的差异均无统计学意义。
提示PRP/BG联合和单纯BG在治疗骨内缺损方面均有效。结果还显示，PRP与BG联合使用在减少牙周袋深度、临床附着增加和缺损填充方面并无额外益处。
