细胞内运输与分泌领域的里程碑式发现。
Landmark discoveries in intracellular transport and secretion.
作者信息
Paknikar Kishore M
机构信息
Agharkar Research Institute, Pune, India.
出版信息
J Cell Mol Med. 2007 May-Jun;11(3):393-7. doi: 10.1111/j.1582-4934.2007.00051.x.
Abstract
Cellular protein transport and secretion is fundamental to the very existence of an organism, regulating important physiological functions such as reproduction, digestion, energy production, growth, neurotransmission, hormone release, water and ion transport, etc., all required for the survival and maintenance of homeostasis within an organism. Molecular understanding of transport and secretion of intracellular product has therefore been of paramount importance and aggressively investigated for over six decades. Only in the last 20 years, the general molecular mechanism of the process has come to light, following discovery of key proteins involved in ER-Golgi transport, and discovery of the porosome the universal secretion machinery in cells.
摘要
细胞蛋白质运输和分泌对于生物体的生存至关重要，它调节着诸如生殖、消化、能量产生、生长、神经传递、激素释放、水和离子运输等重要生理功能，这些都是生物体内维持内环境稳定和生存所必需的。因此，对细胞内产物运输和分泌的分子理解一直至关重要，并在过去六十多年里得到了积极研究。直到最近20年，随着参与内质网-高尔基体运输的关键蛋白质的发现以及细胞中普遍存在的分泌机制——孔体的发现，这一过程的一般分子机制才得以揭示。
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2
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J Cell Mol Med. 2006 Apr-Jun;10(2):273-9. doi: 10.1111/j.1582-4934.2006.tb00398.x.
3
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6
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7
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Cell Biol Int. 2004;28(10):699-708. doi: 10.1016/j.cellbi.2004.07.004.
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