Das-Munshi Jayati, Stewart Rob, Ismail Khalida, Bebbington Paul E, Jenkins Rachel, Prince Martin J
Section of Epidemiology, Institute of Psychiatry, King's College London, London, UK.
Psychosom Med. 2007 Jul-Aug;69(6):543-50. doi: 10.1097/PSY.0b013e3180cc3062. Epub 2007 Jul 16.
To determine a) the associations between diabetes and common mental disorders in a nationally representative sample and the effect of key covariates on such associations and b) the association of comorbid common mental disorders on the quality of life and diabetes self-care indicators.
In a cross-sectional survey, people with diabetes were identified from a sample of 8580 individuals aged 16 to 74 years, drawn from the 2000 UK National Psychiatric Morbidity Survey. Diabetes was ascertained by self-report and prescribed medications. Psychiatric morbidity was assessed using the Revised Clinical Interview Schedule. Quality of life was measured using the Short Form-12, and questions were asked regarding diabetes self-care and functioning.
A total of 249 individuals were identified with diabetes. People with diabetes were more likely to suffer from common mental disorders (odds ratio (OR) = 1.5; 95% Confidence Interval (CI): 1.1-2.2; p < .05), and in particular mixed anxiety and depression (OR: 1.7; 95% CI: 1.1-2.6; p < .05), after controlling for age, gender, ethnicity, and socioeconomic status. The increased risk was uniform across diabetes subtypes. Among people with diabetes, common mental disorders were significantly associated with impaired health-related quality of life, more days off work, nonadherence, and difficulties with diabetes self-care.
People with diabetes are more likely to suffer from common mental disorders, a finding which is highly relevant, given that psychiatric comorbidity in people with diabetes is also associated with higher levels of functional impairment, impaired quality of life, and difficulties with diabetes self-care.
a)在一个具有全国代表性的样本中确定糖尿病与常见精神障碍之间的关联以及关键协变量对此类关联的影响;b)确定共病的常见精神障碍与生活质量及糖尿病自我护理指标之间的关联。
在一项横断面调查中,从2000年英国国家精神疾病发病率调查抽取的8580名16至74岁个体的样本中识别出糖尿病患者。通过自我报告和处方药物确定糖尿病。使用修订后的临床访谈时间表评估精神疾病发病率。使用简短健康调查问卷-12测量生活质量,并询问有关糖尿病自我护理和功能的问题。
共识别出249名糖尿病患者。在控制年龄、性别、种族和社会经济地位后,糖尿病患者更易患常见精神障碍(优势比(OR)=1.5;95%置信区间(CI):1.1 - 2.2;p <.05),尤其是混合性焦虑和抑郁(OR:1.7;95%CI:1.1 - 2.6;p <.05)。糖尿病各亚型的风险增加情况一致。在糖尿病患者中,常见精神障碍与健康相关生活质量受损、更多的误工天数、不依从以及糖尿病自我护理困难显著相关。
糖尿病患者更易患常见精神障碍,鉴于糖尿病患者的精神疾病共病还与更高水平的功能损害、生活质量受损以及糖尿病自我护理困难相关,这一发现具有高度相关性。