Isolation, structure, and coccidiostat activity of coccidiostatin A.

作者信息

Jayasuriya Hiranthi, Guan Ziqiang, Dombrowski Anne W, Bills Gerald F, Polishook Jon D, Jenkins Rosalind G, Koch Leslie, Crumley Tami, Tamas Tamas, Dubois Michelle, Misura Andrew, Darkin-Rattray Sandra J, Gregory Lynn, Singh Sheo B

机构信息

Merck Research Laboratories, P. O. Box 2000, Rahway, New Jersey 07065, USA.

出版信息

J Nat Prod. 2007 Aug;70(8):1364-7. doi: 10.1021/np0700523. Epub 2007 Jul 17.

DOI:10.1021/np0700523

PMID:17636951

Abstract

Coccidiosis is one of the more common and costly diseases in poultry that is caused by various Eimeria species. In our quest to discover coccidiostats from natural products, we discovered a microbial fermentation extract that exhibited in vivo anticoccidial activity. Fractionation of this extract led to the discovery of two potent antiprotozoals, emecorrugatin A (1) and coccidiostatin A (2). The former compound exhibited only in vitro activity, whereas the latter new compound exhibited in vivo activity against Eimeria species in chickens at 150 ppm dosed in chicken feed. The isolation, structure elucidation, relative configuration, and activity of coccidiostatin A (2) are described.

摘要