Gerondakis Steve, Grumont Raelene J, Banerjee Ashish
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Immunol Cell Biol. 2007 Aug-Sep;85(6):471-5. doi: 10.1038/sj.icb.7100097. Epub 2007 Jul 17.
Following encounters with microbes, cellular activation programs that involve the control of proliferation and survival are initiated in follicular B cells either via the B-cell receptor in a specific antigen-defined manner, or through Toll-like receptors (TLRs) that recognize specific microbial products. This review summarizes and discusses recent findings that shed light on how the nuclear factor kappaB pathway controls and coordinates B-cell division and survival following TLR4 engagement.
在与微生物接触后，滤泡B细胞中涉及增殖和存活控制的细胞活化程序会通过B细胞受体以特定抗原定义的方式启动，或者通过识别特定微生物产物的Toll样受体（TLR）启动。本综述总结并讨论了最近的研究发现，这些发现揭示了核因子κB通路在TLR4激活后如何控制和协调B细胞分裂及存活。
