Morgan Daniel J, Guimaraes Luiz H, Machado Paulo R L, D'Oliveira Argemiro, Almeida Roque P, Lago Ednaldo L, Faria Daniela R, Tafuri Wagner L, Dutra Walderez O, Carvalho Edgar M
Division of International Medicine and Infectious Diseases, Weill Medical College of Cornell University, New York, NY 10021, USA.
Clin Infect Dis. 2007 Aug 15;45(4):478-82. doi: 10.1086/520017. Epub 2007 Jul 5.
Cutaneous leishmaniasis affects millions of people worldwide. After observations of atypical lesions in pregnant women at the health centers of Corte de Pedra, Brazil, 9 years of records were reviewed, and 26 pregnant patients were identified. A retrospective case-control study revealed that lesions in pregnant women were much larger than those in nonpregnant patients in an age- and sex-matched group (mean area, 6.08 cm2 vs. 1.46 cm2; P=.008), and many lesions had an exophytic nature. Despite foregoing treatment until after delivery, response to pentavalent antimony therapy was favorable (rate of cure with 1 course of treatment, 85%). High rates of preterm births (10.5%) and stillbirths (10.5%) were reported. Cutaneous leishmaniasis during pregnancy produces distinct lesions and may have adverse fetal effects.
皮肤利什曼病影响着全球数百万人。在巴西科尔特迪佩德拉的健康中心观察到孕妇出现非典型病变后，对9年的记录进行了回顾，确定了26名孕妇患者。一项回顾性病例对照研究显示，在年龄和性别匹配的组中，孕妇的病变比非孕妇患者的病变大得多（平均面积，6.08平方厘米对1.46平方厘米；P = 0.008），并且许多病变具有外生性。尽管在分娩前未进行治疗，但对五价锑疗法的反应良好（1个疗程的治愈率为85%）。据报告早产率（10.5%）和死产率（10.5%）很高。孕期皮肤利什曼病会产生独特的病变，可能对胎儿产生不良影响。
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