Pearson G R, Orr T W
J Natl Cancer Inst. 1976 Mar;56(3):485-8. doi: 10.1093/jnci/56.3.485.
Antibody-dependent lymphocyte cytotoxicity (ADLC) was demonstrated against Epstein-Barr virus (EBV)-infected RAJI cells with peripheral with peripheral blood lymphocytes from EBV-infected donors. No cytotoxic activity was detected against unifected RAJl cells. The results indicated that this antibody-mediated cytotoxic reaction was directed against the same EBV-induced membrane antigens (MA) previously defined by the membrane immunofluorescence (MF) assay. Antibody to EBV-associated early antigens did not participate in this in vitro reaction. Antibody titers to EBV-induced MA were significantly higher by the ADLC assay in comparison with the MF test. A preliminary study showed no relationship between high antibody titers and the presence of EBV-associated malignancies. The possible in vivo significance of this immune reaction was discussed.
用来自感染爱泼斯坦 - 巴尔病毒（EBV）供体的外周血淋巴细胞，针对感染EBV的RAJI细胞证实了抗体依赖性淋巴细胞细胞毒性（ADLC）。未检测到针对未感染的RAJl细胞的细胞毒性活性。结果表明，这种抗体介导的细胞毒性反应针对的是先前通过膜免疫荧光（MF）测定所定义的相同的EBV诱导的膜抗原（MA）。针对EBV相关早期抗原的抗体不参与这种体外反应。与MF试验相比，通过ADLC测定法测得的针对EBV诱导的MA的抗体滴度明显更高。一项初步研究表明，高抗体滴度与EBV相关恶性肿瘤的存在之间没有关系。讨论了这种免疫反应可能的体内意义。
